Some parameters and settings may be exclusive to one environment or the other. Use the Get-CalendarDiagnosticLog cmdlet to collect a range of calendar logs. The Calendar Diagnostic logs track all calendar items and meeting requests in mailboxes. You can use this information to troubleshoot calendar issues that occur in mailboxes.
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Some parameters and settings may be exclusive to one environment or the other. Use the Get-CalendarDiagnosticLog cmdlet to collect a range of calendar logs. The Calendar Diagnostic logs track all calendar items and meeting requests in mailboxes. You can use this information to troubleshoot calendar issues that occur in mailboxes. Values are True or False. Identity: Identifies the mailbox that holds the calendar item. LogDate: The date-time that the calendar item was logged. NormalizedSubject: The Subject field of the calendar item.
For more information, see Get-CalendarDiagnosticAnalysis. You need to be assigned permissions before you can run this cmdlet. To find the permissions required to run any cmdlet or parameter in your organization, see Find the permissions required to run any Exchange cmdlet. In on-premises Exchange organizations, you can use the Get-CalendarDiagnosticAnalysis cmdlet with the LogLocation parameter to analyze the exported. Parameters -Credential This parameter is available only in on-premises Exchange.
Typically, you use this parameter in scripts or when you need to provide different credentials that have the required permissions. A value for this parameter requires the Get-Credential cmdlet. To pause this command and receive a prompt for credentials, use the value Get-Credential. For more information, see Get-Credential.
Abstract Rapid activation of platelets at sites of vascular injury is a critical event in thrombosis and hemostasis. DAG is critical for protein kinase C PKC activation, a key event in platelet granule release and integrin activation [ 1 ]. CalDAG-GEFI activates the small GTPase Rap1, a central molecular switch that drives platelet activation by directly regulating integrin-mediated aggregation [ 2 , 6 , 3 , 4 ] and the release of autocrine agonists [ 5 ]. It is a member of the RasGRP family that includes four guanine nucleotide exchange factors, which differ for tissue expression and target specifity A, table. CalDAG-GEFI amino acids is predominantly expressed in the brain [ 7 ] and, within the hematopoietic lineage, in megakaryocytes and platelets as well as neutrophils [ 2 ]. A longer CalDAG-GEFI splice variant 62 additional N-terminal residues with a different substrate specificity and a different intracellular localization has been proposed, [ 8 ] but the endogenous version has not been identified. It specifically activates Rap1 and Rap2 but lacks Ras exchange activity in vivo [ 7 ].
Human CalDAG-GEFI deficiency increases bleeding and delays αIIbβ3 activation.