Vooral als dit in sterkere mate gebeurt dan normaal, waardoor de inhoud ervan, die voornamelijk uit hemoglobine bestaat, in de vrije bloedbaan vrijkomt. In eerste instantie wordt het vrijkomend hemoglobine gebonden aan haptoglobine , om door het lichaam te worden hergebruikt. Als er niet voldoende haptoglobine meer over is, bindt hemoglobine ook aan andere bloedeiwitten, en wordt het door de nieren uitgescheiden hemoglobinurie , met verkleuring van de urine als gevolg. Een verlaagde hoeveelheid haptoglobine in het bloed is dus een aanwijzing voor hemolyse. Door het verhoogde aanbod van hemoglobine aan het afbraaksysteem in de lever , kan er ook een lichte vorm van geelzucht optreden.

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